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Evidence of liver toxicity may develop in one to four days, although, in severe cases, it may be evident in 12 hours

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Unlike some medications for type 2 diabetes, theyre Although more research is needed, some GLP-1 RAs have also been shown to benefit heart health and kidney function in people with diabetes

5,27 Furthermore, SGLT2 inhibitors reduce sympathetic tone and blood pressure (BP), which would improve afterload

More recently, concerns have been raised that the rapid expanded use may be to patients with less clinical need